Bordetella pertussis: the intersection of genomics and pathobiology
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چکیده
منابع مشابه
Bordetella pertussis: the intersection of genomics and pathobiology.
There has been much recent concern over an increasing incidence of pertussis despite high levels of vaccine coverage of infants. Many reports have documented that much of the increased incidence is due to infection in adolescents and adults. This renewal of interest in pertussis comes at a time when the findings of the Bordetella genome project have led to a quantum leap forward in our understa...
متن کاملComparative genomics of prevaccination and modern Bordetella pertussis strains
Background: Despite vaccination since the 1950s, pertussis has persisted and resurged. It remains a m ajor cause o f in fan t death w o rld w id e and is the m ost prevalent vaccine-preventable disease in developed countries. The resurgence o f pertussis has been associated w ith the expansion o f Bordetella pertussis strains w ith a novel allele for the pertussis tox in (Ptx) prom oter, ptxP3,...
متن کاملBordetella pertussis evolution in the (functional) genomics era.
The incidence of whooping cough caused by Bordetella pertussis in many developed countries has risen dramatically in recent years. This has been linked to the use of an acellular pertussis vaccine. In addition, it is thought that B. pertussis is adapting under acellular vaccine mediated immune selection pressure, towards vaccine escape. Genomics-based approaches have revolutionized the ability ...
متن کاملRegulation of pertussis toxin and lipopolysaccharide levels of Bordetella pertussis 134 in response to modulators
Whooping cough (pertussis) is a highly contagious disease of the human respiratory tract, which is caused by Bordetella pertussis. Reemerge of pertussis in some highly immunized populations and divergency in gene order among several B. pertussis strains promoted this research to study the change of pertussis toxin (PT) and lipopolysacharide levels in response to the different environments. Th...
متن کاملBordetella pertussis and pertussis vaccines.
Bordetella pertussis is a human-specific pathogen that causes whooping cough. The use of pertussis whole-cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life-long immunity; indeed, the circulation of the bacterium has not been controlled in the a...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2005
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.050105